Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
8
We explored the potential of dihydroartemisinin (DHA), a compound derived from an antimalarial drug, to impact glioma stem cells (GSCs). In our study, we found that DHA effectively halted the growth of GSCs and triggered their programmed cell death.
We discovered that DHA influenced the activation of specific proteins that control these processes. In particular, it reduced the activity of p-AKT while boosting Cleaved Caspase-3 levels.
These findings suggest that DHA could offer a promising new method for treating challenging brain tumors like gliomas.
We discovered that DHA influenced the activation of specific proteins that control these processes. In particular, it reduced the activity of p-AKT while boosting Cleaved Caspase-3 levels.
These findings suggest that DHA could offer a promising new method for treating challenging brain tumors like gliomas.
Read More
9
We explored the potential of docosahexaenoic acid (DHA), an omega-3 fatty acid, in fighting glioblastoma, the most aggressive brain tumor. Our study examined various glioblastoma cell lines, discovering that DHA successfully induced cell death through mechanisms like apoptosis and autophagy. Additionally, findings from animal models suggested that DHA reduced tumor size through similar processes. This indicates that DHA could be a promising candidate for future therapies against glioblastoma, potentially improving treatment options for this challenging cancer type.
Read More
8
We explored the effectiveness of docosahexaenoic acid (DHA) liposomes for treating glioblastoma, a tough brain tumor to manage. Using a microfluidic system, we created liposomes of various sizes that were taken in by tumor cells. These DHA liposomes showed a better capacity to reduce cell viability and stimulate cell death compared to regular DHA. This research opens new doors in using omega-3 fatty acids in cancer treatments, highlighting a promising approach to combat this challenging disease.
Read More
Most Useful Reviews
7.5
Improved vision clarity
1 people found this helpful
Take one each morning and after dinner alongside one lutein daily. After two weeks, I have noticed clearer vision and enhanced brain clarity. I intend to continue using it.
Read More
6
Supports brain health
1 people found this helpful
Good product containing docosahexaenoic acid (DHA) at 500 mg and eicosapentaenoic acid (EPA) at 250 mg per capsule. The high dosages are pleasing. The odourless gelatin capsules avoid fish oil's taste, which is a bonus for me. I take one in the morning or at lunchtime, convenient as I don’t have to worry until the next day. This fish oil is sourced from sea anchovies, sardines, or tuna, and quality controls ensure it's free from mercury, lead, and other harmful substances. Omega-3 fatty acids (DHA and EPA) are essential for our diet, supporting heart and brain functions. DHA forms part of cell membranes, enhancing their permeability to water and ions. I strongly recommend this supplement. Be healthy, friends!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8
- All Researches
9
We investigated how glutamine metabolism impacts glioblastoma, paving the way for better treatments. By analyzing large datasets, we classified tumor profiles and examined their unique characteristics.
In a promising approach, we combined the glutaminase inhibitor CB839 with dihydroartemisinin (DHA) and found that this combination significantly affected cancer cell behaviors. This new therapy not only reduced glutamine metabolism but also increased cell death and hindered cancer cell movement.
Overall, our findings suggest that targeting glutamine metabolism with this combination could be an exciting strategy in fighting glioblastoma.
In a promising approach, we combined the glutaminase inhibitor CB839 with dihydroartemisinin (DHA) and found that this combination significantly affected cancer cell behaviors. This new therapy not only reduced glutamine metabolism but also increased cell death and hindered cancer cell movement.
Overall, our findings suggest that targeting glutamine metabolism with this combination could be an exciting strategy in fighting glioblastoma.
Read More
9
We investigated how dihydroartemisinin (DHA), an antimalarial compound, impacts malignant gliomas, known for their aggressive nature and limited treatment options. Our study utilized various assays and animal models, revealing that DHA considerably reduced glioma cell growth, even in resistant strains. It prompted cell death through mitochondrial dysfunction and notably lowered the levels of ERRα, a gene responsible for mitochondrial biogenesis. Additionally, combining DHA with temozolomide enhanced its effectiveness. Overall, our findings highlight DHA's potential in targeting glioma progression by influencing cancer cell metabolism.
Read More
9
We explored the impact of a new hybrid molecule made from sulfasalazine (SAS) and dihydroartemisinin (DHA) on glioma cells, which are tough brain tumors. While SAS didn’t show much promise on its own, DHA significantly reduced cell viability in a dose-dependent manner.
The newly synthesized hybrid, AC254, proved to be even more effective than the individual compounds alone. It not only killed more tumor cells but also affected the cell cycle and limited their movement. This study highlights the potential of combining established drugs to create more powerful treatments for brain tumors.
The newly synthesized hybrid, AC254, proved to be even more effective than the individual compounds alone. It not only killed more tumor cells but also affected the cell cycle and limited their movement. This study highlights the potential of combining established drugs to create more powerful treatments for brain tumors.
Read More
9
We explored the potential of docosahexaenoic acid (DHA), an omega-3 fatty acid, in fighting glioblastoma, the most aggressive brain tumor. Our study examined various glioblastoma cell lines, discovering that DHA successfully induced cell death through mechanisms like apoptosis and autophagy. Additionally, findings from animal models suggested that DHA reduced tumor size through similar processes. This indicates that DHA could be a promising candidate for future therapies against glioblastoma, potentially improving treatment options for this challenging cancer type.
Read More
9
We examined the use of microemulsions (MEs) of curcumin combined with docosahexaenoic acid (DHA) for targeting brain tumors. Both intravenous and intranasal methods showed that the DHA microemulsions delivered significantly higher concentrations of curcumin to the brain, with the intranasal approach proving particularly effective. This enhanced delivery is due to DHA's ability to improve transport across the blood-brain barrier. Notably, we observed promising anticancer activity against human glioblastoma cells, suggesting that these formulations could be a valuable addition to brain cancer therapy.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved vision clarity
1 people found this helpful
Take one each morning and after dinner alongside one lutein daily. After two weeks, I have noticed clearer vision and enhanced brain clarity. I intend to continue using it.
Read More
6
Supports brain health
1 people found this helpful
Good product containing docosahexaenoic acid (DHA) at 500 mg and eicosapentaenoic acid (EPA) at 250 mg per capsule. The high dosages are pleasing. The odourless gelatin capsules avoid fish oil's taste, which is a bonus for me. I take one in the morning or at lunchtime, convenient as I don’t have to worry until the next day. This fish oil is sourced from sea anchovies, sardines, or tuna, and quality controls ensure it's free from mercury, lead, and other harmful substances. Omega-3 fatty acids (DHA and EPA) are essential for our diet, supporting heart and brain functions. DHA forms part of cell membranes, enhancing their permeability to water and ions. I strongly recommend this supplement. Be healthy, friends!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Mendanha D, Casanova MR, Gimondi S, Ferreira H, Neves NM. Microfluidic-Derived Docosahexaenoic Acid Liposomes for Targeting Glioblastoma and Its Inflammatory Microenvironment. ACS Appl Mater Interfaces. 2024;16:40543. doi:10.1021/acsami.4c01368
- Fu H, Wu S, Shen H, Luo K, Huang Z, et al. Glutamine Metabolism Heterogeneity in Glioblastoma Unveils an Innovative Combination Therapy Strategy. J Mol Neurosci. 2024;74:52. doi:10.1007/s12031-024-02201-x
- Zhang W, Wang Y, Chen L, Chen H, Qi H, et al. Dihydroartemisinin suppresses glioma growth by repressing ERRα-mediated mitochondrial biogenesis. Mol Cell Biochem. 2024;479:2809. doi:10.1007/s11010-023-04892-z
- Mendanha D, Gimondi S, Costa BM, Ferreira H, Neves NM. Microfluidic-derived docosahexaenoic acid liposomes for glioblastoma therapy. Nanomedicine. 2023;53:102704. doi:10.1016/j.nano.2023.102704
- Que Z, Zhou Z, Liu S, Zheng W, Lei B. Dihydroartemisinin inhibits EMT of glioma via gene BASP1 in extrachromosomal DNA. Biochem Biophys Res Commun. 2023;675:130. doi:10.1016/j.bbrc.2023.07.019
- Liang J, Li L, Tian H, Wang Z, Liu G, et al. Drug Repurposing-Based Brain-Targeting Self-Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma. Small. 2023;19:e2303073. doi:10.1002/smll.202303073
- Jin R, Xu Y, Jiang P. Inhibitory Effect of Nano-targeted Micelle Administration Combined with in Vitro Radiotherapy on Glioma Based on Nuclear Magnetic Resonance Technology. Cell Mol Biol (Noisy-le-grand). 2022;68:171. doi:10.14715/cmb/2022.68.7.28
- Gong H, Gao M, Lin Y, Liu J, Hu Z, et al. TUG1/MAZ/FTH1 Axis Attenuates the Antiglioma Effect of Dihydroartemisinin by Inhibiting Ferroptosis. Oxid Med Cell Longev. 2022;2022:7843863. doi:10.1155/2022/7843863
- Ackermann A, Çapcı A, Buchfelder M, Tsogoeva SB, Savaskan N. Chemical hybridization of sulfasalazine and dihydroartemisinin promotes brain tumor cell death. Sci Rep. 2021;11:20766. doi:10.1038/s41598-021-99960-z
- Chen M, Cui Y, Hao W, Fan Y, Zhang J, et al. Ligand-modified homologous targeted cancer cell membrane biomimetic nanostructured lipid carriers for glioma therapy. Drug Deliv. 2021;28:2241. doi:10.1080/10717544.2021.1992038
- Choi WS, Xu X, Goruk S, Wang Y, Patel S, et al. FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells. Nutrients. 2021;13. doi:10.3390/nu13082664
- Yi R, Wang H, Deng C, Wang X, Yao L, et al. Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition. Biosci Rep. 2020;40. doi:10.1042/BSR20193314
- Orchard TS, Gaudier-Diaz MM, Phuwamongkolwiwat-Chu P, Andridge R, Lustberg MB, et al. Low Sucrose, Omega-3 Enriched Diet Has Region-Specific Effects on Neuroinflammation and Synaptic Function Markers in a Mouse Model of Doxorubicin-Based Chemotherapy. Nutrients. 2018;10. doi:10.3390/nu10122004
- Kim S, Jing K, Shin S, Jeong S, Han SH, et al. ω3-polyunsaturated fatty acids induce cell death through apoptosis and autophagy in glioblastoma cells: In vitro and in vivo. Oncol Rep. 2018;39:239. doi:10.3892/or.2017.6101
- Shinde RL, Devarajan PV. Docosahexaenoic acid-mediated, targeted and sustained brain delivery of curcumin microemulsion. Drug Deliv. 2017;24:152. doi:10.1080/10717544.2016.1233593
- Cao L, Duanmu W, Yin Y, Zhou Z, Ge H, et al. Dihydroartemisinin exhibits anti-glioma stem cell activity through inhibiting p-AKT and activating caspase-3. Pharmazie. 2014;69:752.
- Ljungblad L, Bergqvist F, Tümmler C, Madawala S, Olsen TK, et al. Omega-3 fatty acids decrease CRYAB, production of oncogenic prostaglandin E and suppress tumor growth in medulloblastoma. Life Sci. 2022;295:120394. doi:10.1016/j.lfs.2022.120394
- Xu X, Wang Y, Choi WS, Sun X, Godbout R. Super resolution microscopy reveals DHA-dependent alterations in glioblastoma membrane remodelling and cell migration. Nanoscale. 2021;13:9706. doi:10.1039/d1nr02128a
- Mena-Hernández J, Jung-Cook H, Llaguno-Munive M, García-López P, Ganem-Rondero A, et al. Preparation and Evaluation of Mebendazole Microemulsion for Intranasal Delivery: an Alternative Approach for Glioblastoma Treatment. AAPS PharmSciTech. 2020;21:264. doi:10.1208/s12249-020-01805-x
- Tan X, Zou L, Qin J, Xia D, Zhou Y, et al. SQSTM1/p62 is involved in docosahexaenoic acid-induced cellular autophagy in glioblastoma cell lines. In Vitro Cell Dev Biol Anim. 2019;55:703. doi:10.1007/s11626-019-00387-8
- Öcal Ö, Nazıroğlu M. Eicosapentaenoic acid enhanced apoptotic and oxidant effects of cisplatin via activation of TRPM2 channel in brain tumor cells. Chem Biol Interact. 2022;359:109914. doi:10.1016/j.cbi.2022.109914
- Yuan Y, Shah N, Almohaisin MI, Saha S, Lu F. Assessing fatty acid-induced lipotoxicity and its therapeutic potential in glioblastoma using stimulated Raman microscopy. Sci Rep. 2021;11:7422. doi:10.1038/s41598-021-86789-9
- Denkins Y, Kempf D, Ferniz M, Nileshwar S, Marchetti D. Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma. J Lipid Res. 2005;46:1278.
- Salvati S, Natali F, Attorri L, Raggi C, Di Biase A, et al. Stimulation of myelin proteolipid protein gene expression by eicosapentaenoic acid in C6 glioma cells. Neurochem Int. 2004;44:331.
- Leaver HA, Bell HS, Rizzo MT, Ironside JW, Gregor A, et al. Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma. Prostaglandins Leukot Essent Fatty Acids. 2002;66:19.
